Cell Signalling

Author: John T. Hancock

Publisher: Oxford University Press

ISBN: 019965848X

Category: Science

Page: 456

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Signalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impactof environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular andintracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource CentreThe Online Resource Centre to accompany Cell Signalling features:For students:* Links to useful websitesFor registered adopters of the text:* Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book* Figures from the book in electronic format for use in lectures

Cell Signaling

principles and mechanisms

Author: Wendell Lim,Bruce Mayer,Tony Pawson

Publisher: Taylor & Francis

ISBN: 1317573625

Category: Science

Page: 416

View: 5830

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Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, components, and logic that drives all signaling, the book develops a conceptual framework through which students can understand how thousands of diverse signaling proteins interact with each other in vast interconnected networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and provide a comprehensive overview of major eukaryotic signaling pathways.

Handbook of Cell Signaling

Author: Ralph A. Bradshaw,Edward A. Dennis

Publisher: Academic Press

ISBN: 0080920918

Category: Science

Page: 3048

View: 5112

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KEY FEATURES: * Contains over 350 chapters of comprehensive coverage on cell signaling * Includes discussion on topics from ligand/receptor interactions to organ/organism responses * Provides user-friendly, well-illustrated, reputable content by experts in the field DESCRIPTION: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors.

Structure and Function in Cell Signalling

Author: John Nelson

Publisher: John Wiley & Sons

ISBN: 0470723734

Category: Science

Page: 416

View: 8486

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"This book contains extremely detailed and informative content on structure and function of ligands, receptors, and signalling intermediates plus interactions … the extent of detail and appropriate referencing is impressive." –Microbiology Today, July 2009 "A very well-written book suitable for use as a reference or textbook for an undergraduate subject in cell signalling. For researchers interested in the molecular basis of cell signalling and how aberrant regulation of cell signalling proteins causes diseases, this is an excellent resource of biochemical and structural information." –Australian Biochemist, August 2009 "From basics to details, this is an elegantly written and carefully edited book. The chapters on cell cycle control and oncogenesis are particularly fascinating and valuable to biomedical research. This is the book to have if you are interested in molecular mechanisms of signal transduction. It is a great introduction to the literature that will be welcomed by students and experts alike." –Doody's, January 2009 This text is a concise and accessible introduction to the dynamic but complex field of signal transduction. Rather than simply cataloguing all signalling molecules and delineating every known pathway, this book aims to break signalling down into common elements and activities – the ‘nuts and bolts’ of cellular information exchange. With an emphasis on clarity of presentation throughout, the book teaches the basic principles focusing on a mature core of knowledge, providing students with a foundation of learning in this complex and potentially confusing subject. It also addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding. An accessible introduction to the complex field of cell signalling Interacts with RasMol software – freely downloadable for viewing structures in 3D Includes exercises and clear instructions in the use of RasMol Well illustrated in full colour throughout Structure and Function in Cell Signalling is an invaluable resource to students across a range of life science degree programmes including biochemistry, cell and molecular biology, physiology, biomedicine and oncology. This book provides a clear, accessible introduction to this rapidly expanding field.

The Biochemistry of Cell Signalling

Author: Ernst J. M. Helmreich

Publisher: Oxford University Press, USA

ISBN: 9780198508205

Category: Science

Page: 328

View: 6023

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'In-depth coverage of the principles of cell signalling... will be an essential purchase for researchers and teachers in this area.' -ChemBioChem'This useful production by Ernst Helmrich is beautifully presented by Oxford University Press. Each contribution is lucid, well illustrated and accompained by extensive reference lists... [a] labour of love... this is a solid enough reference book for the general research student, post-doc and senior investigator who needs to get a reasonable background to cell signalling... a very readable and useful book for background knowledge.' -Cell Biology International'Recommended for everyone working in the area of signal transduction research, who should keep this book at hand for when they want to clarify a particular mechanism or connection again, and to get quick access to the most important original papers and review articles.' -Angewandte ChemieThe Biochemistry of Cell Signalling deals in depth with the principles of cell signalling, concentrating on structure and mechanism. It will serve as a reliable map through the maze of cell signalling pathways and help the reader understand how malfunctions in these pathways can lead to disease. The book is divided into four parts. Part 1 describes the machinery of signal transduction starting with the properties of signals, receptors (including receptor activation), regulators, and the molecules that link receptor and regulator. The design of signalling cascades is explained by describing central signalling pathways: the Ras-regulated MAPK and PI-3 pathways; the Rho/Rac/Cdc 42 pathway controlling chemotaxis and regulating the cytoskeleton; the G protein coupled receptor cascades in response to sensory and hormonal signals; signalling by TGF-ß in morphogenesis; cytokine signalling that controls haemopoiesis. There is also a discussion of the insulin response.

Textbook of Cell Signalling in Cancer

An Educational Approach

Author: Jacques Robert

Publisher: Springer

ISBN: 3319143409

Category: Medical

Page: 328

View: 9420

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This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis. This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.

Cell Signalling in Prokaryotes and Lower Metazoa

Author: I. Fairweather

Publisher: Springer Science & Business Media

ISBN: 9781402017391

Category: Medical

Page: 412

View: 479

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Cell signalling lies at the heart of many biological processes and currently is the focus of intense research interest. In multicellular organisms, it is central to how different types of cell communicate with each other and how they detect and respond to extracellular signals. Intercellular communication is vital to single-celled organisms as well, allowing them to respond to environmental cues and signals. To date, much of the understanding of signalling mechanisms has come from research on specific cell types (eg mouse lymphocyte and cardiomyocyte) or on organisms in which communication systems such as nervous and endocrine systems are well established. This volume therefore aims to 'fill the gap' by concentrating on 'simple organisms' where the elements of those signalling systems first evolved. Many of the groups covered contain important pathogens or parasites, and the potential for manipulating signalling pathways for therapeutic intervention will be highlighted.

Cell signalling

biology and medicine of signal transduction

Author: Barry L. Brown,Pauline R. M. Dobson

Publisher: Raven Pr

ISBN: N.A

Category: Medical

Page: 293

View: 4212

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Stem Cells and Cell Signalling in Skeletal Myogenesis

Author: D.A. Sassoon

Publisher: Elsevier

ISBN: 9780080569734

Category: Science

Page: 152

View: 5108

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Skeletal muscle development is perhaps one of the best understood processes at the molecular, cellular and organismal level due in large part to the fact that primary myogenic cells (myoblasts) will grow and subsequently differentiate into myotubes in culture. With the advent of reverse mouse genetics, many of the observations gained through the study of myogenic cells in vitro have been directly tested in vivo. What has emerged is a complex but cohesive story of how myogenic cells are initially specified in the vertebrate embryo and how muscle fibers ultimately achieve their respective identities (i.e. fast versus slow) to perform their function. This collection of chapters is focused on these developments. The book discusses old and new directions for the skeletal muscle field and points out directions where the field may eventually progress.

Signal Transduction

Author: Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E. R. Tatham

Publisher: Gulf Professional Publishing

ISBN: 9780122896323

Category: Medical

Page: 424

View: 8209

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Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work. * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

Cellular Signal Processing

An Introduction to the Molecular Mechanisms of Signal Transduction

Author: Friedrich Marks,Ursula Klingmüller,Karin Müller-Decker

Publisher: Garland Science

ISBN: 1351677217

Category: Medical

Page: 640

View: 6025

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Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Cell to Cell Signalling

From Experiments to Theoretical Models

Author: A. Goldbeter

Publisher: Academic Press

ISBN: 1483276791

Category: Science

Page: 466

View: 5524

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Cell to Cell Signalling: From Experiments to Theoretical Models is a collection of papers from a NATO Workshop conducted in Belgium in September 1988. The book discusses nerve cells and neural networks involved in signal transfers. The works of Hodgkin and Huxley presents a prototypic combination between experimental and theoretical approaches. The book discusses the coupling process found between secretory cells that modify their behavior. The text also analyzes morphogenesis and development, and then emphasizes the pattern formation found in Drosophila and in the amphibian embryo. The text also cite examples of immunological modeling that is related to the dynamics of immune networks based on idiotypic regulation. One paper analyzes the immune dynamism of HIV infection. The text notes that hormone signaling can be attributed as responsible for intercellular communication. Another paper examines how the dominant follicle in the ovarian cycle is selected, as well as the effectiveness of hormone secretion responsible for encoding the frequency of occurrence of periodic signals. The book also discusses heart signal sources such as cardiac dynamics and the response of periodically excited cardiac cells. The text can prove valuable for practioners in the field of neurology and cardiovascular medicine, and for researchers in molecular biology and molecular chemistry.

Cancer Cell Signalling

Author: Amanda Harvey

Publisher: John Wiley & Sons

ISBN: 1118527755

Category: Medical

Page: 232

View: 6796

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A focused, accessible introduction to this key aspect of cancer biology. It covers the individual cell signalling pathways that are known to be involved in cancer development, and, most important, includes the cross- interactions between the pathways together with the current therapeutic approaches. This is a ‘must-have’ for advanced undergraduate and postgraduate students studying and researching within the field of cancer biology.

Cell-cell Signaling in Bacteria

Author: Gary M. Dunny,Stephen Carlyle Winans

Publisher: ASM Press

ISBN: 9781555811495

Category: Science

Page: 367

View: 705

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"This volume presents the first comprehensive review of bacterial quorum sensing, the signaling processes involved in control of multicellular activities of microbes. It reflects the explosion of knowledge in this area, and the realization that work being done in each of the signaling systems being studied may have important implications for other organisms not closely related by phylogeny or ecological niche."--BOOK JACKET.

Interactions Among Cell Signalling Systems

Author: CIBA Foundation Symposium

Publisher: John Wiley & Sons

ISBN: 0470514213

Category: Science

Page: 280

View: 8162

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A panel of internationally renowned experts present papers on cell signalling--an area in which there has been recent important advances. Coverage includes the inositol 1, 4, 5-triphosphate receptor, signal-induced phospholipid degradation cascade and protein kinase C activation, cyclic AMP interactions in sustained cellular response, the acetylcholine receptor and much more.

Cell to Cell Signalling

From Experiments to Theoretical Models

Author: A. Goldbeter

Publisher: Academic Press

ISBN: 1483276791

Category: Science

Page: 466

View: 3182

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Cell to Cell Signalling: From Experiments to Theoretical Models is a collection of papers from a NATO Workshop conducted in Belgium in September 1988. The book discusses nerve cells and neural networks involved in signal transfers. The works of Hodgkin and Huxley presents a prototypic combination between experimental and theoretical approaches. The book discusses the coupling process found between secretory cells that modify their behavior. The text also analyzes morphogenesis and development, and then emphasizes the pattern formation found in Drosophila and in the amphibian embryo. The text also cite examples of immunological modeling that is related to the dynamics of immune networks based on idiotypic regulation. One paper analyzes the immune dynamism of HIV infection. The text notes that hormone signaling can be attributed as responsible for intercellular communication. Another paper examines how the dominant follicle in the ovarian cycle is selected, as well as the effectiveness of hormone secretion responsible for encoding the frequency of occurrence of periodic signals. The book also discusses heart signal sources such as cardiac dynamics and the response of periodically excited cardiac cells. The text can prove valuable for practioners in the field of neurology and cardiovascular medicine, and for researchers in molecular biology and molecular chemistry.

Molecular Biology of the Cell

Author: Bruce Alberts

Publisher: Garland Science

ISBN: 1317563743

Category: Science

Page: 1464

View: 5302

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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Molecular Chaperones and Cell Signalling

Author: Brian Henderson,A. Graham Pockley

Publisher: Cambridge University Press

ISBN: 9781139444019

Category: Science

Page: N.A

View: 6419

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Originally published in 2005, this book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

Biochemistry of Signal Transduction and Regulation

Author: Gerhard Krauss

Publisher: John Wiley & Sons

ISBN: 3527667490

Category: Science

Page: 844

View: 5076

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Originally based on a graduate course taught by the author, this true classic has once again been extensively updated to incorporate key new findings in biological signaling. With over half of the content re-written, plus 70 brand new and 50 revised figures, this is the most up-to-date textbook on signaling available anywhere. Thanks to its clear structure, hundreds of illustrative drawings, as well as chapter introductions and newly added study questions, this text excels as a companion for a course on biological signaling, and equally as an introductory reference to the field for students and researchers. Generations of students and junior researchers have relied on "the Krauss" to find their way through the bewildering complexity of biological signaling pathways.

Cancer Cell Signalling

Author: Amanda Harvey

Publisher: John Wiley & Sons

ISBN: 1118527755

Category: Medical

Page: 232

View: 4031

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A focused, accessible introduction to this key aspect of cancer biology. It covers the individual cell signalling pathways that are known to be involved in cancer development, and, most important, includes the cross- interactions between the pathways together with the current therapeutic approaches. This is a ‘must-have’ for advanced undergraduate and postgraduate students studying and researching within the field of cancer biology.